Detection of Bacteria in Cerebrospinal Fluid

Meningitis is an inflammatory disease of the tissue surrounding the brain and spinal cord; the lepto-meninges. Diagnosis of infection involving the central nervous system is of critical importance. As laboratories are the front line for detecting bacterial meningitis, molecular-based diagnosis which is rapid and accurate should be adapted for the detection of infectious disease. The book investigation represents a two-stage molecular approach for detection and identification of bacterial meningitis. The presented approach should contribute to better diagnosis of meningitis while saving time, reducing hospitalization days, and increasing both specificity and sensitivity of bacterial detection, effectively enhancing treatment of bacterial meningitis. The work presented here will increase awareness of the progression and emergence of bacterial resistance for antibiotics in hospitals.